Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction
نویسندگان
چکیده
منابع مشابه
Flavonols in the Prevention of Diabetes-induced Vascular Dysfunction
As flavonols are present in fruits and vegetables, they are consumed in considerable amounts in the diet. There is growing evidence that the well-recognized antioxidant, anti-inflammatory, and vasorelaxant actions of flavonols may, at least in part, result from modulation of biochemical signaling pathways and kinases. It is well established that diabetes is associated with increased cardiovascu...
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Arginase can cause vascular dysfunction by competing with nitric oxide synthase for l-arginine and by increasing cell proliferation and collagen formation, which promote vascular fibrosis/stiffening. We have shown that increased arginase expression/activity contribute to vascular endothelial cell (EC) dysfunction. Here, we examined the roles of the two arginase isoforms, arginase I and II (AI a...
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Increases in arginase activity have been reported in a variety of disease conditions characterized by vascular dysfunction. Arginase competes with NO synthase for their common substrate arginine, suggesting a cause and effect relationship. We tested this concept by experiments with streptozotocin diabetic rats and high glucose (HG)-treated bovine coronary endothelial cells (BCECs). Our studies ...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2015
ISSN: 0160-2446
DOI: 10.1097/fjc.0000000000000180